The Texas Department of Public Safety said four people were killed on Interstate 20 Monday afternoon when a truck crossed the median and hit two other vehicles.
It happened in Eastland County, about 75 miles west of Fort Worth, at 1:47 p.m.
A DPS statement said a large truck was headed east down a steep hill when the driver identified as 22-year-old Edward Hallahan of Denton lost control and went over the concrete barrier in the median, hitting a Honda sedan and a Ford pickup truck.
All three occupants of the Honda were killed in the crash. They were identified as Hugo Marin Ulloa, 34, the driver; Erika Valenzuela Ulloa, 34, and three-year-old Max Ulloa. All are from El Paso.
Glyde David Henry, 65, who was driving the Ford pickup, was also killed. A passenger in that vehicle, Janet C. Henry, 62, was injured. Both are from Midland.
DPS said Hallahan and a passenger, 25-year-old Travis Devon Justice of Walnut Hill, Florida, were taken to Harris Methodist Hospital in Fort Worth for treatment of their injuries.
The cause of the crash remains under investigation.