The couple married in 2014 and have been together since 2004.
An attorney for Jolie Pitt, Robert Offer, tells USA TODAY that Jolie has filed for the dissolution of the marriage. "This decision was made for the health of the family," said Offer in a statement. "She will not be commenting at this time, and asks that the family be given their privacy during this difficult time."
Jolie, 41, and Pitt, 52, have six children together: Maddox, Pax, Zahara, Shiloh, and twins Knox and Vivienne.
For 12 years the couple has captivated international audiences with their jet-setting glamour, their commitment to philanthropy, and their red carpet turns. But they put off getting legally married for years, until a surprise ceremony in France in August 2014.
In December 2014 Jolie told Vanity Fair being married did feel different for the couple. "It feels nice to be husband and wife," she said.
Their children helped them write the vows for their ceremony, she said, adding that “They did not expect us never to fight, but they made us promise to always say, ‘Sorry,’ if we do. So they said, ‘Do you?,’ and we said, ‘We do!’ ”
Jolie was previously married to actors Jonny Lee Miller and Billy Bob Thornton. Pitt was previously married to Jennifer Aniston from 2000 to 2005, and the two announced their separation just before the release of Mr. and Mrs. Smith, starring Pitt and Jolie. Though Pitt and Jolie denied infidelity, Pitt later told Rolling Stone he "fell in love" making the movie.
A month after the film's release, the first paparazzi pictures of Pitt and Jolie surfaced.
Pitt later became a legal parent to Jolie's two adopted children, Maddox and Zahara. Jolie gave birth to their first child, Shiloh, in May 2006. Their son Pax was adopted in 2007 from Vietnam, and Jolie gave birth to their twins, Knox and Vivienne, in 2008.
In May 2013 Jolie went public with health issues, revealing that she had decided to undergo a preventative double mastectomy thanks to a blood test that had "revealed that I carried a mutation in the BRCA1 gene," she told the New York Times, that gave her "an estimated 87 percent risk of breast cancer and a 50 percent risk of ovarian cancer."
The same day USA TODAY sat down with Pitt and he brought his hand to his heart, recalling "an emotional and beautifully inspiring few months. And I'll tell you, it's such a wonderful relief to come through this and not have a spectre hanging over our heads."
He called Jolie his "hero," saying "she's still here."
In March 2015 Jolie went public again in an essay revealing she had her ovaries and fallopian tubes removed and had gone through early menopause.
Later that year, promoting their film By the Sea (which was later panned by critics), Pitt told the Today show that "there was no vanity to my wife's approach' to protecting her health. It was mature. 'This is our life and we're gonna make the best of it.' There was a strength in that. It was just another one of those things in life that makes you tighter, and she was doing it for the kids, and she was doing it for her family so we could be together."
Jolie added: "I knew through the surgeries that he was on my side and that this wasn't something where I was gonna feel less of a woman because my husband wasn't gonna let that happen. To face these issues together and speak about them and talk about what it is to be human, I think can be a beautiful thing."
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